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Home > Product > Bio > ATS > Targeted Toxins

Á¦ ǰ ¸í : Targeted Toxins
Á¦ Á¶ »ç : Advanced Targeting Systems
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Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery.

The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent (anything that is recognized on the cell surface and internalized).

The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface.

The conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death.

Cells that do not have the cell surface marker are not affected.

Product

Target

192-IgG-SAP (Cat. #IT-01)

cells that express p75NTR in rat

Acetylated LDL-SAP (Cat. #IT-08)

cells that express microglia in primary cell cultures

Anti-6 His-SAP (Cat. #IT-52)

cells with extracellular expression of 6 His-tagged proteins

Anti-CD103-SAP (Cat. #IT-50)

cells that express CD103

Anti-CD105-SAP (Cat. #IT-80)

cells that express human CD105 (Endoglin)

Anti-CD117-SAP (Cat. #IT-83)

cells that express CD117 in mice

Anti-CD133-SAP (Cat. #IT-82)

cells that express CD133 in human

Anti-CD150-SAP (Cat. #IT-103)

cells that express the CD150 receptor in mice

Anti-CD22-SAP human (Cat. #IT-37)

cells that possess the group-A epitope of the human B-cell antigen, CD22 in human

Anti-CD25-SAP mouse (Cat. #IT-29)

cells that express Interleukin-2 (IL-2) receptor in mouse

Anti-CD38-SAP Kit (Cat. #IT-96)

cells that express mouse CD38 (T10)

Anti-CD44-SAP (Cat. #IT-72)

cells that express all isoforms of the CD44 receptor in multiple species

Anti-CD45.2-SAP (Cat. #IT-91)

cells that express mouse CD45.2 in mouse

Anti-ChAT-SAP (Cat. #IT-42)

cells that express choline acetyltransferase in multiple species

Anti-DAT-SAP (Cat. #IT-25)

cells that express dopamine transporter (DAT-ECD) in rat or human

Anti-DBH-SAP (Cat. #IT-03)

cells that express dopamine beta-hydroxylase in rat

Anti-FLAG (M5)-SAP (Cat. #IT-59)

cells with extracellular expression of FLAG-tagged proteins

Anti-GFP-SAP (Cat. #IT-53)

cells with extracellular expression of GFP-tagged proteins

Anti-PD-L1-SAP (Cat. #IT-45)

cells that express human programmed death-ligand 1 (PD-L1)

Anti-SERT-SAP (Cat. #IT-23)

cells that express serotonin re-uptake transporter

Anti-V5-SAP (Cat. #IT-58)

cells with extracellular expression of V5-tagged proteins

Anti-vGAT-SAP (Cat. #IT-71)

cells that express express the vesicular GABA transporter

Anti-YFP-SAP (Cat. #IT-66)

cells with extracellular expression of YFP and EYFP-tagged proteins

Bombesin-SAP (Cat. #IT-40)

cells that express gastrin releasing peptide (GRP) receptor

CCK-SAP (Cat. #IT-31)

cells that express CCK Receptor

CGRP-SAP (Cat. #IT-94)

cells that express the calcitonin gene-related peptide (CGRP) receptor

Chlorotoxin-SAP (Cat. #IT-86)

cells that express MMP-2 isoforms

CRF-SAP (Cat. #IT-13)

cells that express the corticotropin-releasing factor (hormone) receptor 1

CTB-SAP (Cat. #IT-14)

cells that express the GM1 receptor

Dermorphin-SAP / MOR-SAP (Cat. #IT-12)

cells that express the mu-opioid receptor (MOR)

Dyno-SAP (Dynorphin-SAP) (Cat. #IT-68)

cells that express kappa-opioid receptor

Ex4-SAP (GLP-1-SAP) (Cat. #IT-90)

cells that express GLP-1R

FGF-SAP (Cat. #IT-38)

cells that express FGF receptor

Galanin-SAP (Cat. #IT-34)

cells that express galanin-1 receptor

GAT1-SAP (Cat. #IT-32)

cells that express GABA-1 transporter in mutiple species

Hemokinin 1-SAP (Cat. #IT-76)

cells that express neurokinin-1 (NK-1) receptor

IB4-SAP (Cat. #IT-10)

cells that express ¥á-D-galactopyranoside residues

Kisspeptin-SAP (Cat. #IT-102)

cells that express the human and sheep G-protein coupled receptor, GPR54

Leptin-SAP (Cat. #IT-47)

cells that express leptin receptor

Mac-1-SAP mouse/human (Cat. #IT-06)

cells that express Mac-1 (CD11b) receptor in mouse or human

Mac-1-SAP rat (Cat. #IT-105)

cells that express rat CD11b/c

ME20.4-SAP (Cat. #IT-15)

cells that express p75NTR in multiple species

Melanopsin-SAP (Cat. #IT-44)

cells that express melanopsin in mouse intrinsically photosensitive retinal ganglion cells

MOA-SAP (Cat. #IT-92)

cells that express specific galactose residues

mu p75-SAP (Cat. #IT-16)

cells that express p75NTR in mouse

Neurotensin-SAP (Cat. #IT-56)

cells that express neurotensin receptor

NKB-SAP (Cat. #IT-63)

cells that express NK3 (NKB receptor)

NMB-SAP (Cat. #IT-70)

cells that express Neuromedin B receptor

Nppb-SAP (Cat. #IT-69)

cells that express Neuropeptide natriuretic polypeptide b (Nppb or BNP) receptor

NPY-SAP (Cat. #IT-28)

cells that express the Neuropeptide Y (NPY)

Orexin-B-SAP (Cat. #IT-20)

cells that express the orexin-2 receptor

Oxytocin-SAP (Cat. #IT-46)

cells that express oxytocin receptor

PACAP-SAP (Cat. #IT-84)

cells that express VPAC1, VPAC2, or PAC1 receptors

SSP-SAP (Cat. #IT-11)

cells that express substance P receptor (NK-1)

Trastuzumab (Anti-HER2)-SAP (Cat. #IT-95)

cells that express human HER2

View a complete listing here.

Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery.

The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent (anything that is recognized on the cell surface and internalized).

The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface.

The conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death.

Cells that do not have the cell surface marker are not affected.

Product

Target

192-IgG-SAP (Cat. #IT-01)

cells that express p75NTR in rat

Acetylated LDL-SAP (Cat. #IT-08)

cells that express microglia in primary cell cultures

Anti-6 His-SAP (Cat. #IT-52)

cells with extracellular expression of 6 His-tagged proteins

Anti-CD103-SAP (Cat. #IT-50)

cells that express CD103

Anti-CD105-SAP (Cat. #IT-80)

cells that express human CD105 (Endoglin)

Anti-CD117-SAP (Cat. #IT-83)

cells that express CD117 in mice

Anti-CD133-SAP (Cat. #IT-82)

cells that express CD133 in human

Anti-CD150-SAP (Cat. #IT-103)

cells that express the CD150 receptor in mice

Anti-CD22-SAP human (Cat. #IT-37)

cells that possess the group-A epitope of the human B-cell antigen, CD22 in human

Anti-CD25-SAP mouse (Cat. #IT-29)

cells that express Interleukin-2 (IL-2) receptor in mouse

Anti-CD38-SAP Kit (Cat. #IT-96)

cells that express mouse CD38 (T10)

Anti-CD44-SAP (Cat. #IT-72)

cells that express all isoforms of the CD44 receptor in multiple species

Anti-CD45.2-SAP (Cat. #IT-91)

cells that express mouse CD45.2 in mouse

Anti-ChAT-SAP (Cat. #IT-42)

cells that express choline acetyltransferase in multiple species

Anti-DAT-SAP (Cat. #IT-25)

cells that express dopamine transporter (DAT-ECD) in rat or human

Anti-DBH-SAP (Cat. #IT-03)

cells that express dopamine beta-hydroxylase in rat

Anti-FLAG (M5)-SAP (Cat. #IT-59)

cells with extracellular expression of FLAG-tagged proteins

Anti-GFP-SAP (Cat. #IT-53)

cells with extracellular expression of GFP-tagged proteins

Anti-PD-L1-SAP (Cat. #IT-45)

cells that express human programmed death-ligand 1 (PD-L1)

Anti-SERT-SAP (Cat. #IT-23)

cells that express serotonin re-uptake transporter

Anti-V5-SAP (Cat. #IT-58)

cells with extracellular expression of V5-tagged proteins

Anti-vGAT-SAP (Cat. #IT-71)

cells that express express the vesicular GABA transporter

Anti-YFP-SAP (Cat. #IT-66)

cells with extracellular expression of YFP and EYFP-tagged proteins

Bombesin-SAP (Cat. #IT-40)

cells that express gastrin releasing peptide (GRP) receptor

CCK-SAP (Cat. #IT-31)

cells that express CCK Receptor

CGRP-SAP (Cat. #IT-94)

cells that express the calcitonin gene-related peptide (CGRP) receptor

Chlorotoxin-SAP (Cat. #IT-86)

cells that express MMP-2 isoforms

CRF-SAP (Cat. #IT-13)

cells that express the corticotropin-releasing factor (hormone) receptor 1

CTB-SAP (Cat. #IT-14)

cells that express the GM1 receptor

Dermorphin-SAP / MOR-SAP (Cat. #IT-12)

cells that express the mu-opioid receptor (MOR)

Dyno-SAP (Dynorphin-SAP) (Cat. #IT-68)

cells that express kappa-opioid receptor

Ex4-SAP (GLP-1-SAP) (Cat. #IT-90)

cells that express GLP-1R

FGF-SAP (Cat. #IT-38)

cells that express FGF receptor

Galanin-SAP (Cat. #IT-34)

cells that express galanin-1 receptor

GAT1-SAP (Cat. #IT-32)

cells that express GABA-1 transporter in mutiple species

Hemokinin 1-SAP (Cat. #IT-76)

cells that express neurokinin-1 (NK-1) receptor

IB4-SAP (Cat. #IT-10)

cells that express ¥á-D-galactopyranoside residues

Kisspeptin-SAP (Cat. #IT-102)

cells that express the human and sheep G-protein coupled receptor, GPR54

Leptin-SAP (Cat. #IT-47)

cells that express leptin receptor

Mac-1-SAP mouse/human (Cat. #IT-06)

cells that express Mac-1 (CD11b) receptor in mouse or human

Mac-1-SAP rat (Cat. #IT-105)

cells that express rat CD11b/c

ME20.4-SAP (Cat. #IT-15)

cells that express p75NTR in multiple species

Melanopsin-SAP (Cat. #IT-44)

cells that express melanopsin in mouse intrinsically photosensitive retinal ganglion cells

MOA-SAP (Cat. #IT-92)

cells that express specific galactose residues

mu p75-SAP (Cat. #IT-16)

cells that express p75NTR in mouse

Neurotensin-SAP (Cat. #IT-56)

cells that express neurotensin receptor

NKB-SAP (Cat. #IT-63)

cells that express NK3 (NKB receptor)

NMB-SAP (Cat. #IT-70)

cells that express Neuromedin B receptor

Nppb-SAP (Cat. #IT-69)

cells that express Neuropeptide natriuretic polypeptide b (Nppb or BNP) receptor

NPY-SAP (Cat. #IT-28)

cells that express the Neuropeptide Y (NPY)

Orexin-B-SAP (Cat. #IT-20)

cells that express the orexin-2 receptor

Oxytocin-SAP (Cat. #IT-46)

cells that express oxytocin receptor

PACAP-SAP (Cat. #IT-84)

cells that express VPAC1, VPAC2, or PAC1 receptors

SSP-SAP (Cat. #IT-11)

cells that express substance P receptor (NK-1)

Trastuzumab (Anti-HER2)-SAP (Cat. #IT-95)

cells that express human HER2

View a complete listing here.

 

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