AFFINILUTE™ MIP ß-Agonist

Class selective SPE sorbent for multi-residue extraction of ß-Agonists in urine and tissue samples

ß-agonists are used as feed additives to promote growth in cattle. Their use is banned within Europe, whilst in other countries (e.g. USA, South Africa, and Mexico) they may be used under specific license at low doses. There are 12 ß-agonists in common use and their extraction is often difficult and time consuming, particularly from complex matrices such as muscle tissue. Additionally, it is difficult to extract all ß-agonists using only one method. Using AFFINILUTE MIP - ß-agonist cartridges it is now possible to extract all 12 commonly used ß-agonists with a common methodology.

A broad spectrum of ß-agonists can be extracted from biological samples using AFFINILUTE MIP ß-agonist product e.g. brombuterol, clenbuterol, formoterol, isoxuprine, mapenterol, ractopamine, ritodrine, salbutamol, salmeterol, terbutaline, tulobuterol, zilpaterol and others.

Detection limits are consistent with a reliable survey of drugs of abuse. AFFINILUTE MIP columns have a superior loading capacity compared with immuno-affinity columns. It is recommended to use MS detection for results with forensic validity. It is also possible to use the AFFINILUTE MIP - ß-agonist columns in automated solid-phase extraction systems.

Features and Applications
A broad spectrum of ß-agonists can be extracted from biological samples at extremely low limits of detection and quantification with the AFFINILUTE MIP - ß-agonist columns. The product is class selective for many ß-agonists e.g. brombuterol, clenbuterol, formoterol, isoxuprine, mapenterol, ractopamine, ritodrine, salbutamol, salmeterol, terbutaline, tulobuterol, zilpaterol and others.

Using the molecularly imprinted SPE, the extraction procedure is considerably simplified so that quantification of ß-agonist levels in these types of sample is faster, more robust and ultimately less costly. There is little or no loss of sensitivity in LC-MS/MS due to contamination by interfering compounds. It is also possible to use the AFFINILUTE - ß-agonist cartridges in automated solid-phase extraction systems. Application notes for both HPLC and LC-MS/MS are available.

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